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Hydrochloric Acid → 2,4,5-Tris(4-aminophenyl)oxazole

HRID 2291012
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HRID 2291012 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][C:12]([C:24]3[CH:29]=[CH:28][C:27]([N+:30]([O-])=O)=[CH:26][CH:25]=3)=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][CH:16]=3)[N:14]=2)=[CH:6][CH:5]=1)([O-])=O.CN(C)C=O.Cl.C(=O)([O-])[O-].[Na+].[Na+]>[Fe].O>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[O:11][C:12]([C:24]3[CH:29]=[CH:28][C:27]([NH2:30])=[CH:26][CH:25]=3)=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=3)[N:14]=2)=[CH:8][CH:9]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 10340Sodium CarbonateHCID 137658762,4,5-Tris(4-nitrophenyl)oxazole

생성물 1

HCID 137502642,4,5-Tris(4-aminophenyl)oxazole

시약·촉매·용매 2

HCID 23925Iron촉매
HCID 962
Water
용매

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온도
100 °C

실험 절차

Then, 4.32 g (0.01 mol) of 2,4,5-tris(4-nitrophenyl)oxazole was mixed with 200 ml of N,N-dimethylformamide and 8 g of an iron powder (reduced iron available from Wako Pure Chemical Industries, Ltd.). To the resulting mixture, 4 ml of concentrated hydrochloric acid and 12 ml of water were added, and the mixture was heated to 100° C. while stirring well. After reacting for 1 hour, the reacting solution was neutralized to pH: 8 with a saturated aqueous solution of sodium carbonate, and while maintained at 100° C., it was filtered in a heated state. The filtrate was poured into 1 l of iced water. The white precipitate formed of 2,4,5-tris(4-aminophenyl)oxazole was filtered off and dried. Yield: 3.27 g (96%).

후처리

  1. temperaturewhile maintained at 100° C.
  2. filtrationit was filtered in a heated state
  3. additionThe filtrate was poured into 1 l of iced water

출처 및 근거

ORD 기록
ord-2032d3b4acb44142b85a50e617b0c98f
출처 데이터셋
uspto-grants-1986_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04619881

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