Dimethylformamide → 4-[Bis[2-(acetyloxy)ethyl]amino]benzaldehyde

HRID 2291431노트

반응식

HRID 2291431 반응식
[C:1]([O:4][CH2:5][CH2:6][N:7]([CH2:14][CH2:15][O:16][C:17](=[O:19])[CH3:18])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(=[O:3])[CH3:2].P(Cl)(Cl)(Cl)=O.CN([CH:28]=[O:29])C>>[C:17]([O:16][CH2:15][CH2:14][N:7]([CH2:6][CH2:5][O:4][C:1](=[O:3])[CH3:2])[C:8]1[CH:13]=[CH:12][C:11]([CH:28]=[O:29])=[CH:10][CH:9]=1)(=[O:19])[CH3:18]

참가 물질

4

반응물 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 29521Ethanol, 2,2'-(phenylimino)bis-, 1,1'-diacetate

생성물 1

HCID 3287294-[Bis[2-(acetyloxy)ethyl]amino]benzaldehyde수율 93%

실험 절차

N,N-Di-(2-acetoxyethyl)aniline (A6) (126 g, 0.476 mol) was reacted with phosphorous oxychloride (80.3 g, 0.524 mol) in DMF as for A2 in Example 3. The product was distilled at 155°-175° C. (0.15 mm) to yield 130 g (93%) of A7 as an orange oil.

후처리

  1. distillationThe product was distilled at 155°-175° C. (0.15 mm)

출처 및 근거

ORD 기록
ord-05a49bd50ddd4a34b18906cf3394db88
출처 데이터셋
uspto-grants-1989_01
특허 번호
US04796971

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