Hydrochloric Acid → HCID 54529973, 화합물

HRID 2291567노트

반응식

HRID 2291567 반응식
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[C:12]([CH3:21])[CH:11]=2)[CH2:6][CH2:5]1)(=O)C.Cl>>[CH3:20][S:17]([NH:16][C:13]1[CH:14]=[CH:15][C:10]([N:7]2[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]2)=[CH:11][C:12]=1[CH3:21])(=[O:18])=[O:19]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 21278904HCID 21278904, 화합물

생성물 1

HCID 54529973HCID 54529973, 화합물수율 93.2%

실험 절차

1-Acetyl-4-(4-methanesulphonamido-3-methylphenyl)piperazine (5.93 g) and 2N aqueous hydrochloric acid (85 ml) were refluxed for 2 hours, cooled, evaporated to low bulk, basified with sodium carbonate to pH 9-10 and extracted with 5×100 ml 5% methanol in dichloromethane. The organic layers were combined and evaporated to give the title compound as a brown foam, (4.78 g), m.p. 79°-81°.

후처리

  1. temperaturecooled
  2. customevaporated to low bulk
  3. extractionextracted with 5×100 ml 5% methanol in dichloromethane
  4. customevaporated

출처 및 근거

ORD 기록
ord-b04bc5d87aef4a85979f86901be91526
출처 데이터셋
uspto-grants-1989_01
특허 번호
US04797401

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