Hydrochloric Acid → N-[4-(piperazin-1-yl)phenyl]methanesulfonamide hydrochloride

HRID 2291572노트

반응식

HRID 2291572 반응식
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=O)C.[ClH:21]>>[ClH:21].[CH3:20][S:17]([NH:16][C:13]1[CH:12]=[CH:11][C:10]([N:7]2[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]2)=[CH:15][CH:14]=1)(=[O:18])=[O:19]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 21278916N-[4-(4-Acetylpiperazin-1-yl)phenyl]methanesulfonamide

생성물 1

HCID 18759927N-[4-(piperazin-1-yl)phenyl]methanesulfonamide hydrochloride

실험 절차

1-Acetyl-4-(4-methanesulphonamidophenyl)piperazine (9.6 g) and 5N aqueous hydrochloric acid (100 ml) were heated at 100° for 1 hour, the solvent was evaporated, and the residue dried by azeotroping with toluene. The residue was crystallised from ethanol, yield of the title compound 8.26 g, m.p. 230° (dec.).

후처리

  1. customthe solvent was evaporated
  2. customthe residue dried
  3. customby azeotroping with toluene
  4. customThe residue was crystallised from ethanol, yield of the title compound 8.26 g, m.p. 230° (dec.)

출처 및 근거

ORD 기록
ord-dc7e346d058b47e6802b42e091e5a229
출처 데이터셋
uspto-grants-1989_01
특허 번호
US04797401

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