Hydrochloric Acid → 5-(Trifluoromethyl)isoxazol-3-ylamine

HRID 2291709노트

반응식

HRID 2291709 반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[O:7][N:6]=[C:5]([NH:8]C(=O)C)[CH:4]=1.Cl>C(O)CO>[F:1][C:2]([F:13])([F:12])[C:3]1[O:7][N:6]=[C:5]([NH2:8])[CH:4]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 212792665-Trifluoromethyl-3-acetylaminoisoxazole

생성물 1

HCID 156138795-(Trifluoromethyl)isoxazol-3-ylamine

시약·촉매·용매 1

HCID 174Ethylene Glycol용매

실험 절차

The reaction was carried out according to the same procedure as described in Example 50 except that 5-trifluoromethyl-3-acetylaminoisoxazole (2.21 g, 11.4 mmole), 36% hydrochloric acid (2.89 g, 28.5 mmole) and ehtylene glycol (11.4 ml) were used. The product was then purified by column chromatography on silica gel and further distilled under reduced pressure to give the title compound. Yield: 1.22 g (70.4%), b.p. 84°-85° C./13.0 mmHg.

후처리

  1. customThe product was then purified by column chromatography on silica gel
  2. distillationfurther distilled under reduced pressure

출처 및 근거

ORD 기록
ord-b16fdf4684a24f6ca2d8325886bfd4fa
출처 데이터셋
uspto-grants-1989_01
특허 번호
US04797492

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