Sodium borohydride → 7-Bromo-1,2,3,4-tetrahydro-3,3-dimethyl-1-naphthalenol

HRID 2292041노트

반응식

HRID 2292041 반응식
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][C:7]([CH3:14])([CH3:13])[CH2:8][C:9]2=[O:12])=[CH:4][CH:3]=1.[BH4-].[Na+]>C(O)C>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][C:7]([CH3:14])([CH3:13])[CH2:8][CH:9]2[OH:12])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 157119867-broMo-3,3-diMethyl-3,4-dihydronaphthalen-1(2H)-one

생성물 1

HCID 148194057-Bromo-1,2,3,4-tetrahydro-3,3-dimethyl-1-naphthalenol수율 89%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 7-bromo-3,3-dimethyl-3,4-dihydro-1(2H)-naphthalenone (7.8 g) in dry ethanol (50 ml) at 0° C., was treated with sodium borohydride (1.5 g). The mixture was stirred and allowed to warm to room temperature over 18 hours, and the ethanol removed in vacuo. The residue was partitioned between ethyl acetate and water, and the organic layers were dried and evaporated to give the alcohol as a gum (7.0 g)

후처리

  1. customthe ethanol removed in vacuo
  2. customThe residue was partitioned between ethyl acetate and water
  3. customthe organic layers were dried
  4. customevaporated

출처 및 근거

ORD 기록
ord-967ecdb79aab45dca56c6e3262654798
출처 데이터셋
uspto-grants-1989_01
특허 번호
US04800212

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