Chlorosuccinimide → 4-(2-Chloro-1,2-diphenylethenyl)phenol

HRID 2292495노트

반응식

HRID 2292495 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[Cl:22]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[Cl:22])=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 5074675Phenol, 4-(1,2-diphenylethenyl)-

생성물 1

HCID 45530804-(2-Chloro-1,2-diphenylethenyl)phenol

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Combine (E and Z)-1-[(4-hydroxy)phenyl]-1,2-diphenyl-ethylene [Cacchi et al, Tet. Lets. 25, 3137-3140 (1984)] (0.90 g, 3.31 mmol) and N-chlorosuccinimide (0.486 g, 3.64 mmol) in chloroform (20 mL). Heat to reflux and allow to stir at reflux for 48 hours. Evaporate in vacuo. Chromatograph on silica gel eluting with 20% ethyl acetate/hexane to give the title compound as a solid: mp; 127°-129° C.

후처리

  1. temperatureHeat
  2. temperatureto reflux
  3. temperatureat reflux for 48 hours
  4. customEvaporate in vacuo

출처 및 근거

ORD 기록
ord-5b8a016ac8c54a3ebe026d4090661c33
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05684004

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