4-oxo-4H-1-benzopyran-2-carbonyl chloride → HCID 12752076, 화합물

HRID 2292627노트

반응식

HRID 2292627 반응식
[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[CH:3]=[C:2]1[C:12](Cl)=[O:13].[Cl-].[Al+3].[Cl-].[Cl-]>C1(OC)C=CC=CC=1>[CH3:2][O:1][C:10]1[CH:5]=[CH:6][C:7]([C:12]([C:2]2[O:1][C:10]3[C:5]([C:4](=[O:11])[CH:3]=2)=[CH:6][CH:7]=[CH:8][CH:9]=3)=[O:13])=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 787884-oxo-4H-1-benzopyran-2-carbonyl chlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 12752076HCID 12752076, 화합물

시약·촉매·용매 1

HCID 7519Anisole용매

실험 절차

Combine chromone-2-carboxylic acid chloride (10 mmol), and aluminum chloride (30 mmol) in anisole (70 mL). Heat at reflux for 24 hours. Pour the reaction mixture into ice-water (150 mL). Extract twice with dichloromethane. Dry the separated organic layers over MgSO4, filter, and evaporate in vacuo. Chromatograph on silica gel to give the title compound.

후처리

  1. temperatureHeat
  2. temperatureat reflux for 24 hours
  3. extractionExtract twice with dichloromethane
  4. dry with materialDry the separated organic layers over MgSO4
  5. filtrationfilter
  6. customevaporate in vacuo

출처 및 근거

ORD 기록
ord-784a2e5399874c028d725a65868b5745
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05684017

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