Sodium Hydroxide → 2-chloro-4-(2-2H-1,2,3-triazolylmethyl)phenol

HRID 2292664노트

반응식

HRID 2292664 반응식
CC(C)(C)C([O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]2[N:17]=[CH:16][CH:15]=[N:14]2)=[CH:8][C:7]=1[Cl:18])=O.[OH-].[Na+]>C(O)C>[Cl:18][C:7]1[CH:8]=[C:9]([CH2:12][N:13]2[N:17]=[CH:16][CH:15]=[N:14]2)[CH:10]=[CH:11][C:6]=1[OH:5]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 53869820HCID 53869820, 화합물

생성물 1

HCID 218336772-chloro-4-(2-2H-1,2,3-triazolylmethyl)phenol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 2-chloro-4-(2-2H-1,2,3-triazolyl)methylphenyl 2,2-dimethylpropanoate (3 g), 20% aqueous sodium hydroxide solution (10 ml)and ethanol (60 ml) was heated at reflux for 5 hours. The reaction mixture was then concentrated under reduced pressure, to which water was added, and the mixture was adjusted to pH 6.0 with concentrated hydrochloric acid. This mixture was extracted with ethyl acetate. The organic layer was washed with water, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, which afforded 2-chloro-4-(2-2H-1,2,3-triazolylmethyl)phenol.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 5 hours
  3. concentrationThe reaction mixture was then concentrated under reduced pressure, to which water
  4. additionwas added
  5. extractionThis mixture was extracted with ethyl acetate
  6. washThe organic layer was washed with water
  7. dry with materialdried with anhydrous magnesium sulfate
  8. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-37af69cf8bc84769902228512fb10c3a
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05684022

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