Benzyl Bromide → 4-(Benzyloxy)-2-chloro-1-nitrobenzene

HRID 2293723

반응식

HRID 2293723 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[CH2:12](Br)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 102833-Chloro-4-nitrophenolHCID 11430Potassium Carbonate

생성물 1

HCID 8198614-(Benzyloxy)-2-chloro-1-nitrobenzene

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 3-chloro-4-nitrophenol (10 g, 0.058 mole), benzyl bromide (11.8 g, 0.069 mole), and potassium carbonate (16 g, 0.116 mole) in acetone is stirred, heated at reflux temperature for 17 hours, cooled and filtered. The filtrate is concentrated in vacuo to give a solid residue which is recrystallized from absolute ethanol to give the title compound, mp 82°-84.5° C., identified by elemental and NMR analyses.

후처리

  1. temperatureheated
  2. temperatureat reflux temperature for 17 hours
  3. temperaturecooled
  4. filtrationfiltered
  5. concentrationThe filtrate is concentrated in vacuo
  6. customto give a solid residue which
  7. customis recrystallized from absolute ethanol

출처 및 근거

ORD 기록
ord-6c58a18e95044d748314a8edd22ea2ba
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05686617

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