Sodium Hydroxide → (alphaS)-alpha-Amino-3-thiophenepropanoic acid

HRID 2293911노트

반응식

HRID 2293911 반응식
[OH-].[Na+].O[C:4](=[CH:8][C:9]1[CH:13]=[CH:12][S:11][CH:10]=1)[C:5]([OH:7])=[O:6].[NH2:14][C@H](C([O-])=O)CC([O-])=O>>[CH:13]1[C:9]([CH2:8][C@H:4]([NH2:14])[C:5]([OH:7])=[O:6])=[CH:10][S:11][CH:12]=1

참가 물질

4

반응물 3

HCID 14798Sodium HydroxideHCID 5460541l-aspartic acid, sodium saltHCID 57047889Hydroxy-3-(3-thienyl)acrylic acid

생성물 1

HCID 819083(alphaS)-alpha-Amino-3-thiophenepropanoic acid수율 40%

실험 절차

The procedure was largely as in Example 8. However, solution 1 contained only 20 g of hydroxy-3-(3-thienyl)acrylic acid and 19 g of L-aspartate. The product concentration was 11.5 g/l (58%) after the reaction. After ion-exchange chromatography, 7.9 g (40%) of L-3-(3-thienyl)alanine (2B) were obtained.

후처리

  1. customThe product concentration was 11.5 g/l (58%) after the reaction

출처 및 근거

ORD 기록
ord-6b76fc68f6d942cba8e386e2f0e09052
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05688672

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