1,2-Dichloroethane → 4-Chloro-6-ethylpyrimidine
반응식
[CH2:1]([C:3]1[N:8]=[CH:7][N:6]=[C:5](O)[CH:4]=1)[CH3:2].[Cl:10]CCCl.P(Cl)(Cl)(Cl)=O>O>[Cl:10][C:5]1[CH:4]=[C:3]([CH2:1][CH3:2])[N:8]=[CH:7][N:6]=1참가 물질
5
실험 절차
To 12.4 g (0.1 mole) of 6-ethyl-4-hydroxypyrimidine was added 50 ml of 1,2-dichloroethane, and 18.4 g (0.12 mole) of phosphorus oxychloride was added thereto. The mixture was refluxed by heating for 3 hours. After cooling, water was added to the reaction mixture, and the mixture was extracted with chloroform. The chloroform layer was washed with water and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to obtain 10.38 g of 4-chloro-6-ethylpyrimidine as slightly red liquid.
후처리
- additionwas added
- temperatureThe mixture was refluxed
- temperatureby heating for 3 hours
- temperatureAfter cooling
- extractionthe mixture was extracted with chloroform
- washThe chloroform layer was washed with water
- dry with materialdried over anhydrous sodium sulfate
- customThe solvent was removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-f869e1951ec74966838186c8dd56d581
- 출처 데이터셋
- uspto-grants-1997_11
- 특허 번호
- US05688791
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