2-Dimethylaminopyridine → HCID 178469736, 화합물

HRID 22940

반응식

HRID 22940 반응식
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:3]=1.[C:19]([O:23][C:24]([NH:26][C@H:27]1[CH2:32][CH2:31][C@H:30]([NH2:33])[CH2:29][CH2:28]1)=[O:25])([CH3:22])([CH3:21])[CH3:20].CN(C1C=CC=CN=1)C>C(O)C>[C:19]([O:23][C:24]([NH:26][C@H:27]1[CH2:28][CH2:29][C@H:30]([NH:33][C:2]2[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:3]=2)[CH2:31][CH2:32]1)=[O:25])([CH3:22])([CH3:20])[CH3:21]

참가 물질

5

반응물 3

HCID 218852-DimethylaminopyridineHCID 239537Ethyl 4-chloro-2-phenylpyrimidine-5-carboxylateHCID 178419079HCID 178419079, 화합물

생성물 1

HCID 178469736HCID 178469736, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl 4-chloro-2-phenyl-5-pyrimidinecarboxylate and N-tert-butoxycarbonyl-trans-1,4-cyclohexanediamine were reacted in ethanol in the presence of dimethylaminopyridine in the same manner as in Reference Example 3-49 to obtain N-tert-butoxycarbonyl-trans-4-(5-ethoxycarbonyl-2-phenyl-4-pyrimidinylamino)cyclohexylamine.

출처 및 근거

ORD 기록
ord-9e5d3733bff0495f939a8e37a575b5e3
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06849622B2

연결된 노트

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