Hydrochloric Acid → 2-Methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine hydrochloride

HRID 2294027

반응식

HRID 2294027 반응식
[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:12][CH2:11]2)=[CH:4][N:3]=1.[ClH:24]>CO>[ClH:24].[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][N:10]2[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:14][CH2:15]2)=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 214736142-Methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine

생성물 1

HCID 214737132-Methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine hydrochloride수율 87%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 0.37 g (0.0012 mol) of 2-methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine in 20 ml of methanol was treated with 0.37 ml (0.00129 mol) of 3.5N ethanolic hydrochloric acid, The solution was completely freed from the solvents and the residue was recrystallized from ethanol. 0.36 g (87%) of 2-methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine hydrochloride (1:1.2) was obtained as white crystals; m.p. 240°-242°.

후처리

  1. customthe residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-00c4f20c742949b193696e7c20ead8da
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05688798

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