Hydrochloric Acid → 5-(4-Phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride

HRID 2294033노트

반응식

HRID 2294033 반응식
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[C:15]([NH2:21])=[N:16][C:17]([NH2:20])=[N:18][CH:19]=3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:22]>CO>[ClH:22].[ClH:22].[C:1]1([N:7]2[CH2:8][CH2:9][N:10]([CH2:13][C:14]3[C:15]([NH2:21])=[N:16][C:17]([NH2:20])=[N:18][CH:19]=3)[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 214736725-(4-Phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine

생성물 1

HCID 214737025-(4-Phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride수율 99.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

0.17 g (0.00059 mol) of 5-(4-phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine was dissolved in 120 ml of hot methanol. The solution was treated at room temperature with 0.32 ml (0.00118 mol) of 3.7N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from methanol/diethyl ether. 0.21 g (71%) of 5-(4-phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride was obtained as white crystals; m.p. 275°-277°.

후처리

  1. customthe residue was recrystallized from methanol/diethyl ether

출처 및 근거

ORD 기록
ord-945448211fc845539079e982daa62383
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05688798

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