N-Iodosuccinimide → Methyl 3-iodoimidazo[1,2-a]pyridine-7-carboxylate

HRID 229441노트

반응식

HRID 229441 반응식
C1C(=O)N([I:8])C(=O)C1.[CH3:9][O:10][C:11]([C:13]1[CH:18]=[CH:17][N:16]2[CH:19]=[CH:20][N:21]=[C:15]2[CH:14]=1)=[O:12]>C(#N)C>[CH3:9][O:10][C:11]([C:13]1[CH:18]=[CH:17][N:16]2[C:19]([I:8])=[CH:20][N:21]=[C:15]2[CH:14]=1)=[O:12]

참가 물질

4

반응물 2

HCID 120273N-IodosuccinimideHCID 15096964Methyl imidazo(1,2-a)pyridine-7-carboxylate

생성물 1

HCID 57497695Methyl 3-iodoimidazo[1,2-a]pyridine-7-carboxylate수율 88%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

NIS (1.5 eq, 1.06 mmol, 238 mg) was added in one portion to a stirred solution of imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester (0.705 mmol, 124 mg) in acetonitrile (3 mL). The resulting mixture was stirred overnight. The resulting precipitate was filtered and washed with ethyl acetate. Drying in vacuo at room temperature afforded 3-iodo-imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester in 88% yield. m/z (M+H)=303.1.

후처리

  1. filtrationThe resulting precipitate was filtered
  2. washwashed with ethyl acetate
  3. customDrying in vacuo at room temperature

출처 및 근거

ORD 기록
ord-efda8afd4367441fb36d3814e5cbd0a8
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07563797B2

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