Methanol → BENZYL 2-HYDROXYMETHYLBENZOATE

HRID 2294544노트

반응식

HRID 2294544 반응식
C([C:3]1[CH:18]=[CH:17][C:6]([C:7]([O:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:8])=[CH:5][CH:4]=1)=O.C1C[O:22][CH2:21]C1.CO.[BH4-].[Na+]>O>[OH:22][CH2:21][C:5]1[CH:4]=[CH:3][CH:18]=[CH:17][C:6]=1[C:7]([O:9][CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)=[O:8]

참가 물질

6

반응물 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 4311764Sodium borohydrideHCID 11528845Benzyl 4-formylbenzoate

생성물 1

HCID 11356918BENZYL 2-HYDROXYMETHYLBENZOATE

시약·촉매·용매 1

HCID 962Water용매

실험 절차

10.3 g (43 mmol) of benzyl 4-formylbenzoate, 50 ml of THF and 50 ml of methyl alcohol are introduced into a round-bottomed flask. While cooling in an icebath, 820 mg (21.5 mmol) of sodium borohydride are added in small portions and the mixture is stirred at room temperature for two hours. The reaction medium is poured into water, the mixture is extracted with ethyl ether and the organic phase is separated after settling has taken place, dried over magnesium sulphate and evaporated. 10.4 g (100%) of the expected product, melting point 55°-56° C., are collected.

후처리

  1. additionare added in small portions
  2. extractionthe mixture is extracted with ethyl ether
  3. customthe organic phase is separated after settling
  4. dry with materialdried over magnesium sulphate
  5. customevaporated
  6. custom10.4 g (100%) of the expected product, melting point 55°-56° C., are collected

출처 및 근거

ORD 기록
ord-4bfe0d89e22d4df6a0d3621b852a97c2
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05688817

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