Water → Allyl 4-formylbenzoate

HRID 2294545노트

반응식

HRID 2294545 반응식
[H-].[Na+].[CH:3]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)=[O:4].[CH2:14](Br)[CH:15]=[CH2:16].O>CN(C=O)C>[CH:3]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([O:11][CH2:16][CH:15]=[CH2:14])=[O:10])=[CH:7][CH:6]=1)=[O:4]

참가 물질

6

반응물 4

HCID 962WaterHCID 7841Allyl bromideHCID 120884-Formylbenzoic acidHCID 24758Sodium hydride

생성물 1

HCID 18381245Allyl 4-formylbenzoate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

3.3 g (0.11 mol) of sodium hydride (80% in oil) and 100 ml of DMF are introduced under a stream of nitrogen into a round-bottomed flask. 15 g (0.1 mol) of 4-formylbenzoic acid, dissolved in 200 ml of DMF are added dropwise and the mixture is stirred at room temperature until gaseous evolution has ceased. 9.5 ml (0.11 mol) of allyl bromide are then introduced and the mixture is stirred at room temperature for four hours. The reaction medium is poured into water, the mixture is extracted with ethyl ether and the organic phase is separated after settling has taken place, then dried over magnesium sulphate and evaporated. 19 g (100%) of allyl ester are collected in the form of a slightly yellow oil.

후처리

  1. additionare added dropwise
  2. stirringthe mixture is stirred at room temperature for four hours
  3. extractionthe mixture is extracted with ethyl ether
  4. customthe organic phase is separated after settling
  5. dry with materialdried over magnesium sulphate
  6. customevaporated
  7. custom19 g (100%) of allyl ester are collected in the form of a slightly yellow oil

출처 및 근거

ORD 기록
ord-3e98e8db1e5b4959949376dc639cae8c
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05688817

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