Methanol → HCID 15712257, 화합물

HRID 2294558노트

반응식

HRID 2294558 반응식
[C:1]([C:4]1[CH:15]=[CH:14][C:7]([C:8]([O:10][CH2:11][CH:12]=[CH2:13])=[O:9])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].CO.C1COCC1.[BH4-].[Na+]>O>[OH:3][CH:1]([C:4]1[CH:15]=[CH:14][C:7]([C:8]([O:10][CH2:11][CH:12]=[CH2:13])=[O:9])=[CH:6][CH:5]=1)[CH3:2]

참가 물질

6

반응물 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 4311764Sodium borohydrideHCID 21474599HCID 21474599, 화합물

생성물 1

HCID 15712257HCID 15712257, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

3.1 g (15 mmol) of the allyl ester obtained above in (a), 20 ml of methyl alcohol and 20 ml of THF are introduced into a round-bottomed flask. While cooling in an icebath, 285 mg (7.5 mmol) of sodium borohydride are added in small portions and the mixture is stirred at room temperature for one hour. The reaction medium is poured into water, the mixture is extracted with ethyl ether and the organic phase is separated after settling has taken place, then dried over magnesium sulphate and evaporated. 3.1 g (100%) of the expected product are collected in the form of a colorless oil.

후처리

  1. additionare introduced into a round-bottomed flask
  2. additionare added in small portions
  3. extractionthe mixture is extracted with ethyl ether
  4. customthe organic phase is separated after settling
  5. dry with materialdried over magnesium sulphate
  6. customevaporated
  7. custom3.1 g (100%) of the expected product are collected in the form of a colorless oil

출처 및 근거

ORD 기록
ord-d881ada2f86d4e69902f2b24ce47c5bb
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05688817

반응 노트

불러오는 중…