Lithium hydroxide, monohydrate → HCID 10432719, 화합물

HRID 2294740노트

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HRID 2294740 반응식
O.[OH-].[Li+].C[O:5][C:6](=[O:35])[C@H:7]([CH2:26][C:27]1[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=1)[NH:8][C:9](=[O:25])[CH2:10][C:11]([NH:14][C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16])([CH3:13])[CH3:12]>O.O1CCOCC1>[CH2:18]([O:17][C:15]([NH:14][C:11]([CH3:13])([CH3:12])[CH2:10][C:9]([NH:8][C@H:7]([C:6]([OH:35])=[O:5])[CH2:26][C:27]1[CH:28]=[CH:29][C:30]([O:33][CH3:34])=[CH:31][CH:32]=1)=[O:25])=[O:16])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

참가 물질

5

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 10026366HCID 10026366, 화합물

생성물 1

HCID 10432719HCID 10432719, 화합물

시약·촉매·용매 2

HCID 962Water용매2회HCID 312751,4-Dioxane용매

실험 절차

0.184 g (4.39 mmol) of lithium hydroxide hydrate dissolved in 8 ml of water is added dropwise to a solution of 1.7 g (3.84 mmol) of N-[3-[1-(benzyloxy)formamido]-3-methylbutyryl]-3-(p-methoxyphenyl)-L-alanine methyl ester in 16 ml of dioxan. The solution is stirred at 0° for 1 hour, then treated with 20 ml of water and extracted twice with ether. The aqueous phase is acidified with 6N hydrochloric acid and extracted twice with ether. The combined ether extracts are washed with saturated sodium chloride solution, dried over sodium sulphate and then evaporated under reduced pressure. N-[3-[1-(Benzyloxy)formamido]-3-methylbutyryl]-3-(p-methoxyphenyl)-L-alanine is obtained as a colourless oil, MS: 429 (M+H)+.

후처리

  1. extractionextracted twice with ether
  2. extractionextracted twice with ether
  3. washThe combined ether extracts are washed with saturated sodium chloride solution
  4. dry with materialdried over sodium sulphate
  5. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-0eaab0bb252f4f46986de6e2a8dc6503
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05688946

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