Sodium Hydroxide → 2-Amino-3-bromo-6-methylpyridine

HRID 2294887노트

반응식

HRID 2294887 반응식
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[CH:4][CH:3]=1.[Br:9]Br.[OH-].[Na+]>S(=O)(=O)(O)O.O>[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[Br:9]

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 157652-Amino-6-methylpyridineHCID 24408Bromine

생성물 1

HCID 27344162-Amino-3-bromo-6-methylpyridine수율 55.2%

시약·촉매·용매 2

HCID 962Water용매HCID 1118Sulfuric Acid용매

실험 절차

32.4 g (0.3 mole) of 6-aminopicoline was dissolved in a mixture of 28 g of conc. sulfuric acid and 120 ml of water and the resulting solution was cooled in ice water. 52.8 g (0.33 mole) of bromine was added dropwise to the solution over 30 minutes at 0° C. The reaction solution was stirred for 20 minutes at room temperature and neutralized with cold aqueous NaOH solution. The resultant was filtered and the solid was purified with column chromatography using methylene chloride and ethyl acetate as an eluent to obtain 31 g of the title compound (yield 55%).

후처리

  1. filtrationThe resultant was filtered
  2. customthe solid was purified with column chromatography

출처 및 근거

ORD 기록
ord-3937fc1e153a4492b650464d69a4578b
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05691348

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