2-Chloroaniline → 1-(2-Chlorophenyl)pyrrolidin-2-one

반응식

[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[C:9]1(=O)[O:13][CH2:12][CH2:11][CH2:10]1>>[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[N:4]1[CH2:9][CH2:10][CH2:11][C:12]1=[O:13]

참가 물질

반응물 2

HCID 72402-Chloroaniline

HCID 7302Gamma-Butyrolactone

생성물 1

HCID 41405531-(2-Chlorophenyl)pyrrolidin-2-one수율 25.4%

실험 절차

Following example 19, 12.57 g (0.1M) of 2-chloroaniline and 9.5 g (0.11M) of γ-butyrolactone were heated for 48 hours. The excess starging materials were removed at 50°-80°/0.3 mm. Distillation of the residue gave 4.9 g (25%) of product (45% based on recovered 2-chloroaniline); b.p. 150°-155°/0.3-0.4 mm.

후처리

temperaturewere heated for 48 hours
customThe excess starging materials were removed at 50°-80°/0.3 mm
distillationDistillation of the residue

출처 및 근거

ORD 기록: ord-d9f58c0facda44309451c23641721e5a
출처 데이터셋: uspto-grants-1984_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04424210

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