Ammonia → Aklomide

반응식

[Cl:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[NH3:14]>>[Cl:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:14])=[O:5]

참가 물질

반응물 2

HCID 222Ammonia

HCID 81522Benzoyl chloride, 2-chloro-4-nitro-

생성물 1

HCID 2075Aklomide수율 90%

실험 절차

Thereafter, 2-chloro-4-nitrobenzoyl chloride (450 g, 2.1 m) was added dropwise to a stirred 28% ammonia solution (2,000 ml) at below room temperature between 9° and 16° C. The precipitated reaction mixture was washed with water and 30% methanol and then vacuum-dried to yield 2-chloro-4-nitrobenzamide (379 g, 90%, mp 168°-170° C.).

후처리

customThe precipitated reaction mixture
washwas washed with water and 30% methanol
customvacuum-dried

출처 및 근거

ORD 기록: ord-9cec857d21fd40069e2cb33d97c7ca65
출처 데이터셋: uspto-grants-1984_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04424371

반응 노트

불러오는 중…