Hydrochloric Acid → HCID 13316896, 화합물

HRID 2295521노트

반응식

HRID 2295521 반응식
Cl.C([S:5][CH2:6][CH2:7][C:8]([N:10]1[C@H:14]([C:15]([NH:17][C@H:18]([C:21]([OH:23])=[O:22])[CH2:19][OH:20])=[O:16])[CH2:13][S:12][C@@H:11]1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[OH:30])=[O:9])(=O)C>O.N>[OH:30][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[C@@H:11]1[N:10]([C:8](=[O:9])[CH2:7][CH2:6][SH:5])[C@H:14]([C:15]([NH:17][C@H:18]([C:21]([OH:23])=[O:22])[CH2:19][OH:20])=[O:16])[CH2:13][S:12]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 13316867HCID 13316867, 화합물

생성물 1

HCID 13316896HCID 13316896, 화합물수율 88%

시약·촉매·용매 1

HCID 12896473Azane;hydrate용매

실험 절차

In 10 ml of 28% ammonia water 0.5 g of (2S)-N-[(2R,4R)-[3-(S-acetyl-3-mercaptopropanoyl)-2-(2-hydroxyphenyl)-4-thiazolidinyl]carbonyl]serine is dissolved. The solution is stirred at room temperature for 30 minutes, and acidified with hydrochloric acid after removing excess ammonia. The separated oil is extracted with ethyl acetate. The organic layer is washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and ethyl acetate is removed to give 0.4 g (88%) of the titled compound.

후처리

  1. customafter removing excess ammonia
  2. extractionThe separated oil is extracted with ethyl acetate
  3. washThe organic layer is washed with saturated aqueous sodium chloride solution
  4. dry with materialdried over anhydrous magnesium sulfate, and ethyl acetate
  5. customis removed

출처 및 근거

ORD 기록
ord-3a38fe4b66034452ab42f6eb7bc45767
출처 데이터셋
uspto-grants-1984_01
특허 번호
US04425333

반응 노트

불러오는 중…