Hydrochloric Acid → 4-(Piperidine-4-carbonyl)morpholine hydrochloride

HRID 22956

반응식

HRID 22956 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([OH:16])=O)[CH2:10][CH2:9]1)=O)(C)(C)C.[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1.C(N=C=NCCCN(C)C)C.ON1C2C=CC=CC=2N=N1.[ClH:44]>CN(C)C=O>[ClH:44].[O:20]1[CH2:21][CH2:22][N:17]([C:14]([CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[O:16])[CH2:18][CH2:19]1

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 8083MorpholineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 3928711-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid

생성물 1

HCID 27946894-(Piperidine-4-carbonyl)morpholine hydrochloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture comprising N-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (700 mg), morpholine (319 μL), 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (702 mg), 1-hydroxybenzotriazole (495 mg) and N,N-dimethylformamide (9 ml) was stirred at room temperature for 16 hours to undergo reaction, and the resulting compound was acid-treated with hydrochloric acid to obtain 4-(morpholinocarbonyl)piperidine.hydrochloride.

후처리

  1. customreaction

출처 및 근거

ORD 기록
ord-676d71720fa34c01adc0bfc09583b9d6
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06849622B2

연결된 노트

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