2-Chloro-6,7-dimethoxy-4-quinazolinamine → HCID 20473808, 화합물

HRID 2295733노트

반응식

HRID 2295733 반응식
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[C:4]([Cl:16])[N:3]=1.[C:17]([N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)(=[O:21])/[CH:18]=[CH:19]/[CH3:20]>C(O)CC(C)C>[OH2:12].[ClH:16].[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[C:4]([N:25]2[CH2:26][CH2:27][N:22]([C:17](=[O:21])/[CH:18]=[CH:19]/[CH3:20])[CH2:23][CH2:24]2)[N:3]=1

참가 물질

4

반응물 2

HCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamineHCID 58756641-(Piperazin-1-yl)but-2-en-1-one

생성물 1

HCID 20473808HCID 20473808, 화합물수율 90%

시약·촉매·용매 1

HCID 31260Isoamyl Alcohol용매

실험 절차

To 80 ml of isopentanol were added 4.55 g of 4-amino-2-chloro-6,7-dimethoxyquinazoline and 3.4 g of 1-crotonoylpiperazine; the resulting mixture was then refluxed for 1.5 hours. At the end of this time, the hot reaction mixture was filtered. The filtrate was cooled and the crystals which resulted were collected by filtration and then recrystallized from ethanol to give 3.52 g of the desired hydrochloride hydrate of Compound No. 1 in the form of colourless crystals melting at 255°-256° C. (with decomposition):

후처리

  1. temperaturethe resulting mixture was then refluxed for 1.5 hours
  2. filtrationAt the end of this time, the hot reaction mixture was filtered
  3. temperatureThe filtrate was cooled
  4. customthe crystals which resulted
  5. filtrationwere collected by filtration
  6. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-57021342419c40b6857ab907e9de6161
출처 데이터셋
uspto-grants-1984_01
특허 번호
US04426382

반응 노트

불러오는 중…