Iodoethane → HCID 86739199, 화합물

HRID 2296356노트

반응식

HRID 2296356 반응식
[CH3:1][C:2]1[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=1[CH:4]=[C:5]1[C:9]2=[N:10][C:11]3[CH:12]=[CH:13][C:14]([C:19]([OH:21])=[O:20])=[CH:15][C:16]=3[C:17](=[O:18])[N:8]2[CH2:7][CH2:6]1.[CH2:26](I)[CH3:27].C([O-])([O-])=O.[K+].[K+]>CN(C)C=O>[CH3:1][C:2]1[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=1[CH:4]=[C:5]1[C:9]2=[N:10][C:11]3[CH:12]=[CH:13][C:14]([C:19]([O:21][CH2:26][CH3:27])=[O:20])=[CH:15][C:16]=3[C:17](=[O:18])[N:8]2[CH2:7][CH2:6]1

참가 물질

5

반응물 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 53937337HCID 53937337, 화합물

생성물 1

HCID 86739199HCID 86739199, 화합물수율 83%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

3-(2-methyl-benzylidene)-1,2,3,9-tetrahydro-9-oxo-pyrrolo[2,1-b]quinazoline-7-carboxylic acid (1 g) was reacted with ethyl iodide (0.93 g) and anhydrous K2CO3 (0.83 g) in dimethylformamide (10 ml) under stirring at room temperature for 16 hours. After dilution with ice water the precipitate was filtered and washed with water until neutral: crystallization from chloroform-ethanol gave 0.9 g of 3-(2-methyl-benzylidene)-1,2,3,9-tetrahydro-9-oxo-pyrrolo[2,1-b]quinazoline-7-carboxylic acid, ethyl ester, m.p. 184°-185° C.

후처리

  1. filtrationAfter dilution with ice water the precipitate was filtered
  2. washwashed with water until neutral:
  3. customcrystallization from chloroform-ethanol

출처 및 근거

ORD 기록
ord-afc023879a744a9fbf1f313de4317374
출처 데이터셋
uspto-grants-1984_01
특허 번호
US04428952

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