Hydrochloric Acid → HCID 70514525, 화합물

반응식

[NH2:1][C:2]1[C:3]([C:10]([OH:12])=[O:11])=[CH:4][S:5][C:6]=1[CH2:7][CH2:8][CH3:9].[ClH:13].[CH2:14](O)[CH3:15]>>[ClH:13].[CH2:14]([O:11][C:10]([C:3]1[C:2]([NH2:1])=[C:6]([CH2:7][CH2:8][CH3:9])[S:5][CH:4]=1)=[O:12])[CH3:15]

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 132861584-Amino-5-propylthiophene-3-carboxylic acid

생성물 1

HCID 70514525HCID 70514525, 화합물

실험 절차

A sample of 1.50 g. (8.097 mmols) of 4-amino-5-propyl-3-thiophenecarboxylic acid was dissolved in 75 ml. absolute ethanol which had been previously saturated with gaseous hydrogen chloride. The resulting reaction was heated under reflux for 24 hours, cooled and evaporated to afford 1.43 g. (71%) of pure 4-amino-5-propyl-3-thiophenecarboxylic acid ethyl ester hydrochloride, m.p. 144° C. (dec.) after recrystallization from ethyl acetate.

후처리

customThe resulting reaction
temperaturewas heated
temperatureunder reflux for 24 hours
temperaturecooled
customevaporated
customto afford 1.43 g
custom(71%) of pure 4-amino-5-propyl-3-thiophenecarboxylic acid ethyl ester hydrochloride, m.p. 144° C. (dec.) after recrystallization from ethyl acetate

출처 및 근거

ORD 기록: ord-d4d7f0fe0b3a4170ade8d319d8eadb8a
출처 데이터셋: uspto-grants-1984_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04428963

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