Dimethylformamide → Dimethyl[[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate

HRID 2296463

반응식

HRID 2296463 반응식
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH:12][C:13](=[O:19])[CH:14]([CH2:17][CH3:18])[CH2:15][CH3:16])[CH:10]=2)[N:5]=[CH:4][N:3]=1.CO[CH:22]=[C:23]([C:28]([O:30][CH3:31])=[O:29])[C:24]([O:26][CH3:27])=[O:25].CN(C)C=O>O>[CH2:15]([CH:14]([CH2:17][CH3:18])[C:13]([NH:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][N:3]=[C:2]2[NH:1][CH:22]=[C:23]([C:28]([O:30][CH3:31])=[O:29])[C:24]([O:26][CH3:27])=[O:25])=[O:19])[CH3:16]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 90770Dimethyl methoxymethylenemalonateHCID 130604624-Amino-6-(2-ethylbutyramido)quinazoline

생성물 1

HCID 13060503Dimethyl[[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate수율 56.1%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 4-amino-6-(2-ethylbutyramido)quinazoline (5.58 g), dimethyl methoxymethylenepropanedioate (5.62 g) and N,N-dimethylformamide (22 ml) was stirred at 100° C. for 1.5 hours. After cooling to ambient temperature, water (90 ml) was added to the reaction mixture. The resulting solid was separated by filtration, washed with water and dried to give dimethyl [[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate (4.85 g).

후처리

  1. temperatureAfter cooling to ambient temperature
  2. customThe resulting solid was separated by filtration
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-cea7b45ff99f4210a996cffd7049cf85
출처 데이터셋
uspto-grants-1984_01
특허 번호
US04429126

연결된 노트

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