Sodium hydride → HCID 57056559, 화합물

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[NH2:1][C:2]1[C:7]([C:8]([OH:20])([C:13]#[C:14][C:15]2OC=[CH:18][CH:19]=2)[C:9]([F:12])([F:11])[F:10])=[CH:6][C:5]([Cl:21])=[CH:4][CH:3]=1.[C:22](=[O:25])([O-])[O-].[Cs+].[Cs+].[I-].[Li+].[H-].[Na+]>>[Cl:21][C:5]1[CH:4]=[CH:3][C:2]2[NH:1][C:8](=[O:20])[C@H:7]([CH3:6])[O:20][C@:8]([C:13]#[C:14][C:15]3[CH:19]=[CH:18][O:25][CH:22]=3)([C:9]([F:10])([F:11])[F:12])[C:7]=2[CH:6]=1

참가 물질

반응물 3

HCID 24758Sodium hydride

HCID 54107311HCID 54107311, 화합물

HCID 86755963HCID 86755963, 화합물

생성물 1

HCID 57056559HCID 57056559, 화합물

실험 절차

The title compound was prepared in a manner similar to the product of Example 11 except that cesium carbonate/lithium iodide rather than sodium hydride was used in the final reaction step: mp 214-215°.

후처리

customreaction step

출처 및 근거

ORD 기록: ord-2a26931c89b54c9293b5e1d46faf3f58
출처 데이터셋: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06489320B1

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