Sodium Hydroxide → 2,2'-{Propane-2,2-diylbis[(4,1-phenylene)oxy]}diacetic acid

HRID 2296895노트

반응식

HRID 2296895 반응식
C([O:3][C:4]([CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([C:17]2[CH:29]=[CH:28][C:20]([O:21][CH2:22][C:23]([O:25]CC)=[O:24])=[CH:19][CH:18]=2)([CH3:16])[CH3:15])=[CH:10][CH:9]=1)=[O:5])C.[OH-].[Na+]>CO>[C:23]([CH2:22][O:21][C:20]1[CH:19]=[CH:18][C:17]([C:14]([C:11]2[CH:10]=[CH:9][C:8]([O:7][CH2:6][C:4]([OH:5])=[O:3])=[CH:13][CH:12]=2)([CH3:16])[CH3:15])=[CH:29][CH:28]=1)([OH:25])=[O:24]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 12359780HCID 12359780, 화합물

생성물 1

HCID 123597752,2'-{Propane-2,2-diylbis[(4,1-phenylene)oxy]}diacetic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

6.7 g of ethyl 4-[1-(4-ethoxycarbonylmethoxyphenyl)-1-methylethyl]phenoxyacetate are dissolved in 20 ml of methanol, and 16.7 g of 10% strength sodium hydroxide solution are added. The mixture is heated to boiling under reflux for 3 hours, after which it is cooled down and the methanol is then distilled off on a rotary evaporator. The residue is diluted with water and acidified to pH 2 with 2 N HCl; the colorless precipitate is then filtered off with suction, washed with water and dried in vacuo over calcium chloride. 5.5 g of the title compound, having a m.p. of 177-179° C., are obtained.

후처리

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 3 hours
  3. temperatureafter which it is cooled down
  4. distillationthe methanol is then distilled off on a rotary evaporator
  5. additionThe residue is diluted with water
  6. filtrationthe colorless precipitate is then filtered off with suction
  7. washwashed with water
  8. dry with materialdried in vacuo over calcium chloride
  9. customare obtained

출처 및 근거

ORD 기록
ord-c02c2dc1e12c45c69cd88e7ef1676e72
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06489327B1

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