Phosphorus tribromide → 3-(1-(Benzyloxyimino)ethyl)benzylbromide

HRID 2296970노트

반응식

HRID 2296970 반응식
[CH2:1]([O:8][N:9]=[C:10]([C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=1)[CH2:15]O)[CH3:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(Br)(Br)[Br:21]>C(OCC)C>[CH2:1]([O:8][N:9]=[C:10]([C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=1)[CH2:15][Br:21])[CH3:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 867586303-(1-(Benzyloxyimino)ethyl)benzylalcohol

생성물 1

HCID 734333223-(1-(Benzyloxyimino)ethyl)benzylbromide수율 194.2%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a solution of 2.55 g (10 mmol) of 3-(1-(benzyloxyimino)ethyl)benzylalcohol in 20 ml of dry diethyl ether was added dropwise 1.35 g (4.5 mmol) of phosphorous tribromide with ice-cooling. The mixture was removed from an ice bath and stirred at room temperature for 6 hours. To the reaction mixture were added ice water and diethyl ether. The mixture was stirred for 30 minutes and separated. The organic layer was washed successively with an about 5% aqueous solution of sodium bicarbonate and water, then dried and concentrated to obtain 2.78 g (8.74 mmol) of 3-(1-(benzyloxyimino)ethyl)benzylbromide.

후처리

  1. temperaturecooling
  2. customThe mixture was removed from an ice bath
  3. additionTo the reaction mixture were added ice water and diethyl ether
  4. stirringThe mixture was stirred for 30 minutes
  5. customseparated
  6. washThe organic layer was washed successively with an about 5% aqueous solution of sodium bicarbonate and water
  7. customdried
  8. concentrationconcentrated

출처 및 근거

ORD 기록
ord-9185698488d54e1086fed725b3e01fad
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06489487B1

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