Bromide ion → HCID 135458024, 화합물

HRID 229731

반응식

HRID 229731 반응식
[CH3:1][CH:2]1[CH2:11][C:10]2[N:9]=[N:8][C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=3)=[CH:6][C:5]=2[C:4](=[O:22])[CH2:3]1.[Br-].C(=O)(O)[O-].[Na+]>C(OCC)(=O)C>[CH3:1][C:2]1[CH:3]=[C:4]([OH:22])[C:5]2[CH:6]=[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=3)[N:8]=[N:9][C:10]=2[CH:11]=1

참가 물질

5

반응물 3

HCID 259Bromide ionHCID 516892Sodium BicarbonateHCID 100180127-methyl-3-(3-trifluoromethylphenyl)-7,8-dihydro-6H-cinnolin-5-one

생성물 1

HCID 135458024HCID 135458024, 화합물수율 5.6%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매3회

실험 절차

To an ethyl acetate solution (1 mL) of 7-methyl-3-(3-trifluoromethylphenyl)-7,8-dihydro-6H-cinnolin-5-one (306 mg, 1.0 mmol) obtained in Example 66 was added cupuric bromide (446 mg, 2.0 mmol), followed by reaction under heating and refluxing for 8 hours, adding saturated sodium bicarbonate aqueous solution (2 mL) to the reaction liquid and extraction with ethyl acetate. To residue obtained after concentration of an organic layer under reduced pressure was added ethyl acetate (1 mL) and filtered off solid obtained to get an objective product (17 mg, 5.5%) as yellow solid.

후처리

  1. customfollowed by reaction
  2. temperatureunder heating
  3. temperaturerefluxing for 8 hours
  4. customTo residue obtained after concentration of an organic layer under reduced pressure
  5. filtrationfiltered off solid
  6. customobtained

출처 및 근거

ORD 기록
ord-ff26126a4628438c9be7a02cf30b4270
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07563893B2

연결된 노트

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