Sodium Hydroxide → Benzyl D-valinate

HRID 2297967노트

반응식

HRID 2297967 반응식
[OH-].[Na+].FC(F)(F)C(O)=O.[CH2:10]([O:17][C:18](=[O:24])[C@@H:19]([CH:21]([CH3:23])[CH3:22])[NH2:20])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(Cl)Cl>[CH2:10]([O:17][C:18](=[O:24])[C@@H:19]([CH:21]([CH3:22])[CH3:23])[NH2:20])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 69764497d-Valine benzyl ester trifluoroacetic acid salt

생성물 1

HCID 7350007Benzyl D-valinate수율 83%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1 N Sodium hydroxide (80 mL) was added to a solution of D-valine benzyl ester trifluoroacetic acid salt (10 g, 31.1 mmol) in methylene chloride (80 mL) and the reaction mixture was stirred until all the starting material was converted to the free amine. The organic phase was collected and washed with brine, dried over magnesium sulfate, and concentrated to give D-valine benzyl ester (5.35 g) as a clear oil.

후처리

  1. customThe organic phase was collected
  2. washwashed with brine
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-de066459fd214151bc2e2182022b30d0
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06492394B1

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