Triethylamine → 2-Ethyltricyclo[3.3.1.1~3,7~]decan-2-yl prop-2-enoate

HRID 2298738노트

반응식

HRID 2298738 반응식
[CH2:1]([C:3]1([OH:13])[CH:10]2[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:12][CH:4]1[CH2:5]3)[CH2:9]2)[CH3:2].C(N(CC)CC)C.[C:21](Cl)(=[O:24])[CH:22]=[CH2:23]>CC(CC(C)C)=O>[C:21]([O:13][C:3]1([CH2:1][CH3:2])[CH:4]2[CH2:12][CH:8]3[CH2:7][CH:6]([CH2:11][CH:10]1[CH2:9]3)[CH2:5]2)(=[O:24])[CH:22]=[CH2:23]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 13140Acryloyl chlorideHCID 44019512-Ethyl-2-adamantanol

생성물 1

HCID 221688802-Ethyltricyclo[3.3.1.1~3,7~]decan-2-yl prop-2-enoate수율 80%

시약·촉매·용매 1

HCID 7909Methyl Isobutyl Ketone용매

반응 조건

온도
40 °C

실험 절차

180 g of 2-Ethyl-2-adamantanol, 303 g of triethylamine and 500 g of methylisobutyl ketone were mixed by stirring at 40° C. While stirring, 136 g of acrylic acid chloride was added dropwise to the mixture. After completion of the dropwise addition, the mixture was stirred for three more hours. Then, extraction and distillation were conducted to obtain 2-ethyl-2-adamantyl acrylate at the yield of 80%.

후처리

  1. stirringWhile stirring
  2. additionAfter completion of the dropwise addition
  3. stirringthe mixture was stirred for three more hours
  4. extractionThen, extraction and distillation

출처 및 근거

ORD 기록
ord-f978f646b1ed48bebdf242c9bf9a7a76
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06495307B2

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