Potassium Carbonate → Ethyl 3-[benzyl(2-methoxy-2-oxoethyl)amino]butanoate

HRID 2299105

반응식

HRID 2299105 반응식
[CH2:1]([NH:8][CH:9]([CH3:16])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:18][C:19]([O:21][CH3:22])=[O:20].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH2:1]([N:8]([CH2:18][C:19]([O:21][CH3:22])=[O:20])[CH:9]([CH3:16])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 236384Ethyl 3-(benzylamino)butanoate

생성물 1

HCID 18379207Ethyl 3-[benzyl(2-methoxy-2-oxoethyl)amino]butanoate수율 82.3%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A suspension of ethyl 3-(benzylamino)butanoate (5.9 g, 26.7 mmol), methyl bromoacetate (3.0 ml, 31.7 mmol) and potassium carbonate (7.4 g, 53.5 mmol) in acetonitrile (100 ml), was stirred at room temperature for 18 hs. The reaction was filtered through celite and concentrated to give ethyl 3-[benzyl(2-methoxy-2-oxoethyl)amino]butanoate (6.45 g, 82%) as a clear oil, MS (M+H)+=294.

후처리

  1. filtrationThe reaction was filtered through celite and
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1172e6df8a92440db103cfa3ddf1bc7d
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06495565B2

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