Hydrochloric Acid → Methyl 3-(3-(aminomethyl)phenyl)propanoate hydrochloride

HRID 2300573

반응식

HRID 2300573 반응식
[CH3:1][O:2][C:3](=[O:14])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]#[N:13])[CH:7]=1.[ClH:15]>[Pd].CO>[ClH:15].[CH3:1][O:2][C:3](=[O:14])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][NH2:13])[CH:7]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 53396017Methyl 3-(3-cyanophenyl)prop-2-enoate

생성물 1

HCID 22282736Methyl 3-(3-(aminomethyl)phenyl)propanoate hydrochloride

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 3-(3-cyano-phenyl)-acrylic acid methyl ester of Step B (1.37 g, 7.32 mmol), 10% palladium on carbon (1.0 g), and HCl (4N in dioxane, 3 mL) in MeOH (50 mL) was hydrogenated on a Parr shaker at 50 psi for 65 h. The catalyst was removed by filtration through Celite and the solution was concentrated to provide the title compound (1.97 g). 1H NMR (400 MHz, CD3OD) δ 7.25-7.24 (m, 4H), 4.06 (s, 2H), 3.60 (s, 3H), 2.92 (t, 2H), 2.64 (t, 2H).

후처리

  1. customThe catalyst was removed by filtration through Celite
  2. concentrationthe solution was concentrated

출처 및 근거

ORD 기록
ord-b03681122cf6430bb97eea4e1acf3a60
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06498172B1

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