Hydrochloric Acid → HCID 12398997, 화합물

HRID 2301261노트

반응식

HRID 2301261 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=O)[CH:10](Br)[CH3:11])=[CH:5][CH:4]=1.[CH3:14][O:15][C:16]1[CH:21]=C[C:19](OC)=[CH:18][CH:17]=1.C[N:25](C)C1C=CC=CC=1.Cl>>[CH3:14][O:15][C:16]1[CH:21]=[C:11]2[C:19](=[CH:18][CH:17]=1)[NH:25][C:9]([C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)=[CH:10]2

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 949N,N-DimethylanilineHCID 90161,4-DimethoxybenzeneHCID 2991022-Bromo-1-(4-methoxyphenyl)propan-1-one

생성물 1

HCID 12398997HCID 12398997, 화합물

실험 절차

A solution of p-methoxy-2-bromopropiophenone ((1 g, 4.11 mmol) was added to a solution of p-methoxyanisole in N,N dimethylaniline (1.7 g, 13.82 mmol)) and heated under reflux for 3 hours. The reaction mixture was cooled to room temperature, poured into 2N HCl, and extracted with EtOAc. The organic extract was washed with water and dried over Na2SO4. Removal of the solvent under reduced pressure and flash chromatography on SiO2 using CH2Cl2 gave the desired intermediate compound 2.

후처리

  1. temperatureheated
  2. temperatureunder reflux for 3 hours
  3. extractionextracted with EtOAc
  4. extractionThe organic extract
  5. washwas washed with water
  6. dry with materialdried over Na2SO4
  7. customRemoval of the solvent under reduced pressure and flash chromatography on SiO2

출처 및 근거

ORD 기록
ord-3def2fc80867488f818c85d12d1174e2
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06500669B1

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