Water → HCID 86588376, 화합물

반응식

[O:1]1[CH2:5][CH2:4][CH2:3][N:2]1[C:6]1[CH:11]=[C:10]([Cl:12])[C:9]([S:13]([NH2:16])(=[O:15])=[O:14])=[C:8](Cl)[C:7]=1[N+:18]([O-:20])=[O:19].[H-].[Na+].[OH2:23]>>[O:1]1[CH2:5][CH2:4][CH2:3][N:2]1[C:6]1[CH:11]=[C:10]([Cl:12])[C:9]([S:13]([NH2:16])(=[O:15])=[O:14])=[C:8]([OH:23])[C:7]=1[N+:18]([O-:20])=[O:19]

참가 물질

반응물 3

HCID 962Water

HCID 24758Sodium hydride

HCID 86587417HCID 86587417, 화합물

생성물 1

HCID 86588376HCID 86588376, 화합물수율 53.3%

실험 절차

Following the general hydrolysis procedure outlined in example 15, (N-tetrahydroisoxazyl)-2,6 -dichloro-3-nitrobenzenesulfonamide (0.1 g, 0.29 mmol), 80% NaH (26 mg, 0.88 mmol) and water (6.3 μL, 0.35 mmol) were reacted to form the desired product (50 mg, 53%). LC-MS m/z 323(M+).