Hydrochloric Acid → HCID 18677713, 화합물

HRID 2301753노트

반응식

HRID 2301753 반응식
Cl.C([Cl:5])(=O)C.[CH2:6]([O:13][C:14]([N:16]([CH:20]1[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]1)[CH2:17][CH2:18][CH3:19])=[O:15])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(OCC)(=O)C>CO>[ClH:5].[CH2:6]([O:13][C:14]([N:16]([CH:20]1[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]1)[CH2:17][CH2:18][CH3:19])=[O:15])[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 8857Ethyl AcetateHCID 186776841,1-Dimethylethyl 4-[[(phenylmethoxy)carbonyl]propylamino]-1-piperidinecarboxylate

생성물 1

HCID 18677713HCID 18677713, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 2.4 mmol of HCl in 2 mL of methanol (prepared by the addition of 0.17 mL of acetyl chloride at 0° C. and stirring for 10 min) was added 90 mg of 4-(N-(benzyloxycarbonyl)-N-(prop-1-yl)amino)-1-t-butoxycarbonylpiperidine. The mixture was stirred at rt for 16 h at which time the reaction was complete by TLC (20% ethyl acetate in hexanes) and was evaporated to dryness in vacuo to afford 75 mg of the title compound as the hydrochloride salt.

후처리

  1. stirringThe mixture was stirred at rt for 16 h at which time the reaction
  2. customwas evaporated to dryness in vacuo

출처 및 근거

ORD 기록
ord-1582f23a9f554cf6b8fcc8c7eb9f8182
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06500844B1

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