Sodium Hydroxide → 4-(3-Methylanilino)-2-[(2-ureidoethyl)amino]pyrimidine-5-carboxamide

HRID 2303312노트

반응식

HRID 2303312 반응식
[O-:1][C:2]#[N:3].[K+].Cl.O1CCOCC1.[NH2:12][CH2:13][CH2:14][NH:15][C:16]1[N:21]=[C:20]([NH:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([CH3:29])[CH:24]=2)[C:19]([C:30]([NH2:32])=[O:31])=[CH:18][N:17]=1.[OH-].[Na+]>O1CCOCC1.O>[CH3:29][C:25]1[CH:24]=[C:23]([CH:28]=[CH:27][CH:26]=1)[NH:22][C:20]1[C:19]([C:30]([NH2:32])=[O:31])=[CH:18][N:17]=[C:16]([NH:15][CH2:14][CH2:13][NH:12][C:2]([NH2:3])=[O:1])[N:21]=1

참가 물질

7

반응물 4

HCID 14798Sodium HydroxideHCID 98173492-(2-Aminoethylamino)-4-(m-tolylamino)pyrimidine-5-carboxamideHCID 11378442Potassium cyanateHCID 204431481,4-Dioxane hydrochloride

생성물 1

HCID 184608294-(3-Methylanilino)-2-[(2-ureidoethyl)amino]pyrimidine-5-carboxamide

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

A 147 mg portion of potassium cyanate and 450 μl of 4 M hydrochloric acid-dioxane solution were added to a mixture of 312 mg of 2-(2-aminoethylamino)-4-(3-methylanilino)pyrimidine-5-carboxamide and 3 ml of water and 3 ml of 1,4-dioxane, followed by stirring at room temperature for 1 day. The reaction mixture was alkalified by adding 1 M sodium hydroxide aqueous solution, and the thus formed precipitate was collected by filtration. The filtered material was washed by stirring it in methanol while heating and then collected by filtration to obtain 212 mg of 4-(3-methylanilino)-2-[(2-ureidoethyl)amino]pyrimidine-5-carboxamide (colorless solid).

후처리

  1. filtrationthe thus formed precipitate was collected by filtration
  2. washThe filtered material was washed
  3. stirringby stirring it in methanol
  4. temperaturewhile heating
  5. filtrationcollected by filtration

출처 및 근거

ORD 기록
ord-ba3eff2c6e214304bc183c3df6a17171
출처 데이터셋
uspto-grants-2002_08
특허 번호
US06432963B1

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