Phosphorus oxychloride → 1-Chloro-7-methoxyisoquinoline

HRID 2304296노트

반응식

HRID 2304296 반응식
Cl.[CH3:2][O:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][N+:10]([O-])=[CH:11]2)=[CH:6][CH:5]=1.P(Cl)(Cl)([Cl:17])=O>>[Cl:17][C:11]1[C:12]2[C:7](=[CH:6][CH:5]=[C:4]([O:3][CH3:2])[CH:13]=2)[CH:8]=[CH:9][N:10]=1

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 226656837-Methoxy-isoquinoline-N-oxide hydrochloride

생성물 1

HCID 222501811-Chloro-7-methoxyisoquinoline

반응 조건

온도
90 °C

실험 절차

7-Methoxy-isoquinoline-N-oxide hydrochloride (38.2 g) was added in portions to phosphoryl chloride (275 mL) and the mixture heated at 90° C. for 6 h. Excess of phosphoryl chloride was removed in vacuo. The remaining white solid was washed with water, filtered and dried in vacuo.

후처리

  1. customExcess of phosphoryl chloride was removed in vacuo
  2. washThe remaining white solid was washed with water
  3. filtrationfiltered
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-3efc43c5009b47909fc38669bd0e214b
출처 데이터셋
uspto-grants-2002_08
특허 번호
US06432955B1

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