Sodium borohydride → HCID 11047852, 화합물

HRID 2304559노트

반응식

HRID 2304559 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][C:18]=1[F:19])[N:15]=[C:14]([I:20])[C:13]([CH:21]=[O:22])=[CH:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+]>CO>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][C:18]=1[F:19])[N:15]=[C:14]([I:20])[C:13]([CH2:21][OH:22])=[CH:12]2)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 22987158HCID 22987158, 화합물

생성물 1

HCID 11047852HCID 11047852, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A suspension of 6-benzyloxy-7-fluoro-2-iodo-3-quinolinecarbaldehyde (obtained according to 1.e, 13 g, 32 mmol) in methanol (100 ml) is treated with sodium borohydride (1.85 g, 48 mmol). After 1 hour of reaction, the reaction medium is concentrated under reduced pressure then taken up with water, filtered, washed with water and ethanol in order to produce, after drying under reduced pressure, 10 g (76%) of a white solid, m.p. 188° C.

후처리

  1. customAfter 1 hour of reaction
  2. concentrationthe reaction medium is concentrated under reduced pressure
  3. filtrationfiltered
  4. washwashed with water and ethanol in order
  5. customto produce
  6. dry with materialafter drying under reduced pressure, 10 g (76%) of a white solid, m.p. 188° C.

출처 및 근거

ORD 기록
ord-ea7d5449aba440ba9a6ce7d826699629
출처 데이터셋
uspto-grants-2002_08
특허 번호
US06436951B1

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