Toluene → 2-Methacryloyloxy-4,4-dimethyl-gamma-butyrolactone

HRID 2305281

반응식

HRID 2305281 반응식
[OH:1][CH:2]1[CH2:7][C:6]([CH3:9])([CH3:8])[O:5][C:3]1=[O:4].[C:10](Cl)(=[O:14])[C:11]([CH3:13])=[CH2:12].C(N(CC)CC)C.C1(C)C=CC=CC=1>O>[C:10]([O:1][CH:2]1[CH2:7][C:6]([CH3:9])([CH3:8])[O:5][C:3]1=[O:4])(=[O:14])[C:11]([CH3:13])=[CH2:12]

참가 물질

6

반응물 4

HCID 1140TolueneHCID 8471TriethylamineHCID 13528Methacryloyl chlorideHCID 101977032-Hydroxy4,4-dimethyl-gamma-butyrolactone

생성물 1

HCID 219544892-Methacryloyloxy-4,4-dimethyl-gamma-butyrolactone수율 85%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
25 °C

실험 절차

A mixture of 100 mmole of the above-prepared 2-hydroxy4,4-dimethyl-γ-butyrolactone, 150 mmole of methacrylic chloride, 150 mmole of triethylamine, and 300 ml of toluene was stirred at 25° C. for 4 hours. Water was added to the reaction mixture, the organic layer was then concentrated, and the concentrate was subjected to column chromatography on a silica gel to yield 2-methacryloyloxy-4,4-dimethyl-γ-butyrolactone in a yield of 85%.

후처리

  1. concentrationthe organic layer was then concentrated

출처 및 근거

ORD 기록
ord-d4b53fe675724568b381d4c716ec6c72
출처 데이터셋
uspto-grants-2002_08
특허 번호
US06440636B1

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