p-Toluenesulfonic acid → (3E)-4,4-dimethoxy-3-methoxyiminopentan-2-one

HRID 2306147

반응식

HRID 2306147 반응식
[CH3:1][O:2][N:3]=[C:4]([C:8](=[O:10])[CH3:9])[C:5](=[O:7])[CH3:6].[CH:11](OC)(OC)[O:12]C.[C:18]1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[CH3:1][O:2]/[N:3]=[C:4](/[C:8]([O:12][CH3:11])([O:10][CH3:18])[CH3:9])\[C:5](=[O:7])[CH3:6]

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 9005Trimethyl orthoformateHCID 536122Diacetyl(methoxyimino)methane

생성물 1

HCID 11263949(3E)-4,4-dimethoxy-3-methoxyiminopentan-2-one수율 98%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

4.3 g (0.03 mol) of pentane-2,3,4-trione 3-(O-methyloxime) and 6.2 g (0.06 mol) of trimethyl orthoformate were dissolved in 15 ml of methanol and admixed with a spatula tip of p-toluenesulfonic acid. The mixture was subsequently stirred at 50° C. for 5 h, after which the solvent was distilled off. This gave 5.5 g of an oil (98% yield) (phys. data see Tab. 1).

후처리

  1. distillationafter which the solvent was distilled off

출처 및 근거

ORD 기록
ord-38e7166334d248c4a58ba74da6ee54ed
출처 데이터셋
uspto-grants-2002_08
특허 번호
US06441236B1

연결된 노트

불러오는 중…