Trimethyl orthoformate → (1E)-1-methoxyimino-1-(2-methyl-1,3-dioxan-2-yl)propan-2-one

HRID 2306149

반응식

HRID 2306149 반응식
[CH3:1][O:2][N:3]=[C:4]([C:8](=[O:10])[CH3:9])[C:5](=[O:7])[CH3:6].[CH2:11](O)[CH2:12][CH2:13][OH:14].C(OC)(OC)OC>C1(C)C=CC(S(O)(=O)=O)=CC=1>[CH3:1][O:2]/[N:3]=[C:4](/[C:8]1([CH3:9])[O:14][CH2:13][CH2:12][CH2:11][O:10]1)\[C:5](=[O:7])[CH3:6]

참가 물질

5

반응물 3

HCID 9005Trimethyl orthoformateHCID 104421,3-PropanediolHCID 536122Diacetyl(methoxyimino)methane

생성물 1

HCID 22967233(1E)-1-methoxyimino-1-(2-methyl-1,3-dioxan-2-yl)propan-2-one수율 94.6%

시약·촉매·용매 1

HCID 6101p-Toluenesulfonic acid촉매

실험 절차

Starting from 103 g (0.72 mol) of pentane-2,3,4-trione 3-(O-methyloxime), 275 g (3.62 mol) of 1,3-propanediol, 80 g (0.76 mol) of trimethyl orthoformate and 1.6 g of p-toluenesulfonic acid (9 mmol) and using the procedure of Example 2, 137 g (94% yield) of a reddish oil were obtained which, according to HPLC, had a purity of 70% (phys. data see Tab. 1).

출처 및 근거

ORD 기록
ord-1a4ddb7dcb0a428fa40c4d3c6cb35015
출처 데이터셋
uspto-grants-2002_08
특허 번호
US06441236B1

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