Triethylamine → N-[(4-bromophenyl)methyl]-1-pyrrolidinecarboxamide

HRID 230635

반응식

HRID 230635 반응식
[Br:1][C:2]1[CH:11]=[CH:10][C:5]([CH2:6][N:7]=[C:8]=[O:9])=[CH:4][CH:3]=1.[CH2:12]([N:14](CC)[CH2:15][CH3:16])[CH3:13].N1CCCC1>C(#N)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][NH:7][C:8]([N:14]2[CH2:15][CH2:16][CH2:13][CH2:12]2)=[O:9])=[CH:10][CH:11]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31268PyrrolidineHCID 43746174-Bromobenzyl isocyanate

생성물 1

HCID 57762826N-[(4-bromophenyl)methyl]-1-pyrrolidinecarboxamide수율 99.7%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 4-bromobenzylisocyanate (408 mg, 1.92 mmol) in acetonitrile (15 ml) was treated with triethylamine (390 mg, 3.86 mmol) followed by pyrrolidine (137 mg, 1.93 mmol) at room temperature with stirring under argon. The reaction was stirred at 20° C. for 30 minutes and then partitioned between ethyl acetate (10 ml) and water (20 ml). The organic layer was dried over sodium sulphate and evaporated under reduced pressure to give the title compound as a colourless solid (542 mg, 99%).

후처리

  1. stirringThe reaction was stirred at 20° C. for 30 minutes
  2. custompartitioned between ethyl acetate (10 ml) and water (20 ml)
  3. dry with materialThe organic layer was dried over sodium sulphate
  4. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-f443a1ad5c914714b68e4eed5bc82f15
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07566735B2

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