Hydrochloric Acid → 239113-23-6

HRID 2306856노트

반응식

HRID 2306856 반응식
[Cl:1][C:2]1[C:3]([CH:12]([N:20]=C(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.Cl>C(OCC)C>[ClH:1].[Cl:1][C:2]1[C:3]([CH:12]([NH2:20])[CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 22629930HCID 22629930, 화합물

생성물 1

HCID 69351932239113-23-6

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a solution of the product from stage b) (1.29 g) in diethyl ether (5 ml) was added 1M hydrochloric acid (10 ml) at room temperature and the solution was stirred at room temperature for 2 hours. The mixture was filtered to give a solid, which was washed with water (15 ml) then ether (15 ml). Drying in vacuo gave the title product. Water was removed from the aqueous phase by azeotropic distillation with toluene (×3), to give further quantities of the title product.

후처리

  1. filtrationThe mixture was filtered
  2. customto give a solid, which
  3. washwas washed with water (15 ml)
  4. customDrying in vacuo

출처 및 근거

ORD 기록
ord-bb3e168c11bd4080b841a93b67be50ad
출처 데이터셋
uspto-grants-2004_12
특허 번호
US06828441B2

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