Trifluoroacetic anhydride → 4H,5H,6H-7lambda5-pyrrolo[1,2-c][1,2,3]oxadiazol-7-ylium-3-olate

HRID 2307250노트

반응식

HRID 2307250 반응식
[N+:1]([N:4]1[CH2:11][CH2:10][CH2:9][C@H:5]1[C:6]([OH:8])=[O:7])([O-])=O.FC(F)(F)C(OC(=O)C(F)(F)F)=O>CCOCC>[N:1]1[O:7][C:6]([O-:8])=[C:5]2[CH2:9][CH2:10][CH2:11][N+:4]=12

참가 물질

4

반응물 2

HCID 9845Trifluoroacetic anhydrideHCID 211172671-Nitro-L-proline

생성물 1

HCID 150890374H,5H,6H-7lambda5-pyrrolo[1,2-c][1,2,3]oxadiazol-7-ylium-3-olate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

N-Nitroproline (17.0 g, 118 mmol) was suspended in ether (400 ml) and cooled in ice. Trifluoroacetic anhydride (16.5 ml, 120 mmol) was then added dropwise over 30 minutes and the mixture left to warm to room temperature whilst stirring over 16 hours. The mixture was evaporated in vacuo to an oil and purified by column chromatography on silica gel using an eluant of ethyl acetate to afford the title compound, 9.8 g.

후처리

  1. temperaturecooled in ice
  2. waitthe mixture left
  3. customThe mixture was evaporated in vacuo to an oil
  4. custompurified by column chromatography on silica gel using an eluant of ethyl acetate

출처 및 근거

ORD 기록
ord-dd8f782405ce47f28831dfbf6f7f42ff
출처 데이터셋
uspto-grants-2004_12
특허 번호
US06831074B2

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