Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 1-Nicotinoyl-3-phenyl-2-pyrazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3-Pyridinecarbonyl chloride, hydrochloride (1:1) | HCID 88438 | — |
| 반응물 | 3-Phenyl-4,5-dihydro-1H-pyrazole | HCID 589745 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 1-Nicotinoyl-3-phenyl-2-pyrazoline | HCID 9819657 | 74.2% |
반응 단계
3-Phenyl-2-pyrazoline (2.9 g) synthesized in Reference Example 2 was dissolved in chloroform (20 ml). Thereto were added nicotinic acid chloride hydrochloride (4 g) and triethylamine (6 ml) with ice-cooling. Stirring was conducted for 30 minutes at room temperature. The reaction mixture was washed with water and concentrated under vacuum. The residue was purified by silica gel column chromatography (methanol:chloroform=1/100) to obtain 3.7 g of a title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06831083B2 |
| 출처 데이터셋 | uspto-grants-2004_12 |
| ORD ID | ord-6893ebef7bf741d3bf85b5185d3d46de |
| 출처 메모 | uspto-grants-2004_12 |